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Gout linked to 376 genetic variants in a study of 2.6 million people

As well as being caused by eating a high-fat diet, gout has been linked to hundreds of genetic variants in the largest study of its kind

By Carissa Wong

16 December 2022

X-ray of feet affected by gout

X-ray of feet affected by gout

Yok_onepiece/Shutterstock

Almost 400 genetic variants have been linked to gout in the largest study of its kind.

Gout is a type of arthritis that leads to painful flare-ups around joints. The condition is caused by a build-up of uric acid, or urate, from the breakdown of molecules called purines. This causes urate crystals to form in joints, leading to a painful inflammatory response.

Purines are made in the body and found in certain foods and drinks, such as bacon and beer. Drinking alcohol in moderation …

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